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Sickle cell conditions are inherited from parents in much the same way as blood type, hair color and texture, eye color and other physical traits. The types of hemoglobin a person makes in the red blood cells depend upon what hemoglobin genes the person inherits from his or her parents. Like most genes, hemoglobin genes are inherited in two sets, one from each parent.
If one parent has Sickle Cell Anemia (SS disease) and the other is Normal, all of the children will have sickle cell trait.
If one parent has Sickle Cell Anemia (SS) and the other has Sickle Cell Trait (AS), there is a 50% chance (or 1 out of 2) of having a baby with either sickle cell disease or sickle cell trait with each pregnancy.
When both parents have Sickle Cell Trait, they have a 25% chance (1 of 4) of having a baby with sickle cell disease with each pregnancy.
Types of Sickle Cell Disease - There are several types of sickle cell disease. The most common are:
• Hemoglobin SS Disease • Hemoglobin SC Disease • Sickle Beta-Plus Thalassemia • Sickle Beta-Zero Thalassemia.
The majority of individuals with sickle cell disease have hemoglobin S, but some make a different type of abnormal hemoglobin like hemoglobin
C, hemoglobin D, or hemoglobin E. Also, some individuals can have sickle cell disease because of co-inheritance of beta thalassemia. It is important to speak to your physician to understand what type you have.